My At-Home PRF/PRP Method for Glowier Skin & Thicker Hair

DIY-Style Guide: PRF vs PRP for Skin & Hair — And Exactly How I Do My Process

If you’re into glow-boosting, collagen-stimulating, under-eye-brightening magic, you’ve probably heard of PRP and PRF. I use both regularly for skin and hair, and today I’m breaking down the difference between them — plus a realistic DIY-style look at the exact process I follow when I’m doing my own treatments at home.

(Obviously, this is for educational purposes only. I’m a nurse, but you should always consult a professional before poking your own face.)

PRP vs PRF: What’s the Difference?

Think of them like two versions of your body’s growth-factor serum.

PRP (Platelet-Rich Plasma)

• Spun at higher speeds

• Produces a thin golden plasma full of platelets

• Releases growth factors fast

• Best for: microneedling, acne scars, texture, general skin rejuvenation

PRF (Platelet-Rich Fibrin)

• Spun at lower speeds with NO anticoagulant

• Creates a thicker, gel-like fibrin matrix

• Releases growth factors slowly for 7–10 days

• Best for: under-eye hollows, hair restoration, fine lines, areas needing volume + long-lasting regeneration

PRP = quick burst

PRF = slow drip

I use both depending on what I’m targeting.

My Actual DIY Process (Face + Under Eyes + Scalp)

This is the exact way I do my treatments, step-by-step. Again — educational purposes only, babes.

STEP 1: Prep Your Space

I set everything up clean, organized, and ready before drawing any blood.

My setup includes:

• Alcohol wipes

• 10 mL Vacutainer tubes (PRP)

• 10 mL PRF tubes (no anticoagulant)

  

  The PRF tubes I use. Product LINK on Amazon. I might earn a commission.

• Butterfly needle

  

  The Butterfly Needle set I use. LINK on Amazon, I sometimes earn a commission.

• Syringes + blunt cannulas

  

  25g 35mm Blunt Cannula. LINK to the ones I use. I might earn commission.

  
  

• My centrifuge

  

  ONiLAB Benchtop Centrifuge. LINK to product on Amazon, I might earn a small commission.

  
  

• Gauze

• Numbing cream

Everything laid out = smooth process.

STEP 2: Draw the Blood

I usually draw two tubes:

• 1 PRP tube for microneedling

• 1 PRF tube for under-eyes or scalp

If I’m doing hair only, I might do just PRF.

STEP 3: Spin the Tubes

This is the part people mess up, so here’s exactly what I do:

PRP Spin

• High speed

• Longer spin

• Goal: separate the plasma into a clear, golden fluid

PRF Spin

• Low speed

• Shorter spin

• No anticoagulant

• Goal: keep living cells, fibrin, and platelets intact so it forms a soft, gel-like serum

  Your Exact Settings for PRF & PRP on the OMNILAB DM0506

  💛 PRF (Platelet-Rich Fibrin) — LOW SPIN

  PRF MUST be low g-force since it uses no anticoagulant.

  Set to:

  • RCF (g-force): 200–300 gMost accurate

  • Time: 5–8 minutes

  • Mode: P2 (slow stop)

  If you want it in RPM instead of RCF, this equals:

  RPM: ~1300–1500 RPM

  This gives you the thick, cloudy, fibrin-rich layer that forms your “gel.”

  ✨ PRP (Platelet-Rich Plasma) — HIGH SPIN

  PRP uses anticoagulant tubes, so fast spin is fine.

  Set to:

  • RCF: 1200–1500 g

  • Time: 10–12 minutes

  • Mode: P1 (fast stop)

  In RPM, this equals:

  RPM: ~3200–3500 RPM

  This produces the clear golden plasma layer you draw off the top.

  ⭐ Recommended Programs to Save on Your Machine

  P1 = PRP

  • 3500 RPM

  • 10:00 minutes

  • Fast stop (quick braking)

  P2 = PRF

  • 1400 RPM

  • 5:00–8:00 minutes

  • Slow stop (gentle braking)

  This prevents the PRF clot from ripping or separating.

When the timer goes off, PRP looks watery, PRF looks cloudy/thicker.

STEP 4: Collect the Good Stuff

I use a sterile syringe to pull off the layers:

• For PRP: I withdraw the top golden layer

• For PRF: I gather the soft, buffy fibrin layer

PRF starts thickening fast — like within minutes — so I always inject that first.

STEP 5: Treat the Area

UNDER EYES (My Favorite Use for PRF)

• I use a 25g cannula and go through a small entry point near the outer eye.

• I slowly lay tiny threads of PRF in the tear trough and orbital hollow.

• No filler look – it’s subtle, hydrated, lifted.

• I like that PRF keeps releasing growth factors for days and doesn’t migrate like HA fillers.

FACE (PRP for Glow)

If I’m microneedling:

• Apply a thin layer of PRP as slip

• Microneedle it into the skin

• Add another light coat afterward

This gives the “glass-skin next day” effect.

The Dr. Pen device I use to Microneedle. LINK to Amazon. I sometimes earn a commission.

SCALP (PRF + PRP for Hair)

When I’m doing scalp mesotherapy:

• I usually use PRF if I want long-lasting stimulation

• Or PRP when I’m stacking with exosomes or copper peptides

I inject tiny micro-boluses across the thinning zones (especially my temples) in a grid pattern.

STEP 6: Aftercare

My personal rules:

• No makeup for 24 hours

• No heavy sweating

• No retinoids or acids for 3–5 days

• Lots of hydration and gentle products

Under-eyes from PRF look puffy at first — totally normal. It smooths out beautifully over 48 hours.

Which One Should You Use?

Here’s the quick cheat sheet based on what I actually see in my own results:

PRF

• Under eyes

• Hairline/temples

• Fine lines needing “cushion”

• Long-term regeneration

PRP

• Overall glow

• Texture

• Microneedling sessions

• Acne scarring

I alternate the two depending on what I’m treating that night.

Final Thoughts

PRP and PRF are literally your own bio-boosters — powerful, natural, and customizable. Whether you want brighter under-eyes, thicker hair regrowth, or smoother skin, both options deliver insane results when used right.

This is the exact process I follow in my own DIY aesthetic routine, and it’s one of my favorite ways to keep my skin bright, my hairline full, and everything looking fresh. Check out my DIY Microneedling guide and if you're comfortable with syringes, look at my guides on peptides.